In addition to the adverse events above, potentially important events that occurred in at least two patients subjects exposed to losartan or other adverse events that occurred in of patients in clinical studies are listed below. It is converted, in part, to an active carboxylic acid metabolite that is responsible for most of the angiotensin II receptor antagonism that follows losartan treatment. Many of the company biggest products suffered sales declines, including asthma treatment Singulair and Gardasil, vaccine against cervical cancer whose revenue declined by third. Patients with severe congestive heart failure treatment with angiotensin converting enzyme comprar cozaar alimentados ex - inhibitors has been associated with oliguria and or progressive azotemia and rarely with acute renal failure and or death.